• First class II fusion proteins are known to

  2022-02-11

  

  First, class II fusion proteins are known to transition from a (homo- or hetero-) pre-fusion dimer to a post-fusion trimer [57], [58], [59], [60], [61], [62] through a monomeric intermediate [63], [64], and a crystalline structure of a monomer of Rift Valley fever virus (a phlebovirus, member of the

• During the tests in vitro SHP showed the beneficial effect

  2022-02-11

  

  During the tests in vitro, SHP289-04 showed the beneficial effect on both two important aspects. In human liver carcinoma cell line HepG2, it was found to improve glucose consumption significantly. Otherwise, in pancreas cell line NIT1, it could only promote insulin secretion significantly at high g

• After the successful development of

  2022-02-10

  

  After the successful development of molecular targeted drugs in lung adenocarcinoma, substantial efforts have been made to provide similar targeted drugs in lung squamous-cell carcinoma. Because FGFR gene alteration is the most frequent occurrence in squamous-cell carcinoma, targeted therapies for F

• High lipophilicity of seems to cause poor

  2022-02-10

  

  High lipophilicity of seems to cause poor PK profiles. First we replaced the phenyl ring of compound with various hetero aromatic rings to reduce lipophilicity, (). The synthesis of pyridine derivative was shown in . (2′,6′-Dimethylbiphenyl-3-yl)methanol () was reacted with 2,5-dibromopyridine i

• Naringin Interestingly the subcellular localization of

  2022-02-10

  

  Interestingly, the subcellular localization of FBPase in hepatocytes and proximal tubule Naringin reveals that FBPase is also able to translocate to the nucleus in these cell types. The nuclear localization of muscle-FBPase was recently reported [35]. This data corroborate our results on the abilit

• Although drug monitoring is not

  2022-02-10

  

  Although drug monitoring is not usually requested, there are some cases where measurement of DOACs in EHop-016 receptor is useful, and of special help for managing patients at risk. These cases include the control of adherence to a therapeutic protocol, surveillance of drug accumulation risk in long

• br Materials and methods br

  2022-02-10

  

  Materials and methods Results Discussion mmLDL is an important risk factor for cardiovascular disease, but its mechanism is still unclear. Previously, we co-cultured mmLDL with the coronary artery and basilar artery and found that mmLDL could upregulate ETB receptor expression in both [16],

• SU5416 The cases of the Berlin and London

  2022-02-10

  

  The cases of the Berlin and London patients also highlight our limits to defining an HIV cure. No signs of the virus have been found in numerous assays with multiple samples from diverse tissues that Timothy Brown has generously contributed to advance research over the past 12 years. In the case of

• In this study we also

  2022-02-10

  

  In this study, we also profiled the expression of the transporters in wild-type RBL-2H3 cells, RBL-2H3 Sc98 cells, and rat peritoneal mast cells. OCT1 and PMAT were expressed at high levels in both RBL-2H3 Sc98 and RBL-2H3 cells. However, OCT2 and OCT3 were weakly or least detected in RBL-2H3 Sc98 c

• Successful immune escape will be then followed by cancer dev

  2022-02-10

  

  Successful immune escape will be then followed by cancer development, along with which immunocytes infiltration occurs. While some immunocytes are born to sweep away the malignancy, others aim to neutralize the lethality and sustain immune anergy and tolerance [59,60]. And the latter one is well rep

• br Conflict of interest br Introduction Endometriosis is def

  2022-02-10

  

  Conflict of interest Introduction Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus, most often in the pelvic peritoneum and ovaries. This disorder affects an estimated 10% of women in the reproductive age group and is basically an estrogen-dependent

• Letermovir Anti apoptotic Bcl proteins have become

  2022-02-10

  

  Anti-apoptotic Bcl-2 proteins have become attractive targets for anti-cancer agents development, because they are associated with progression of a wide variety of human cancers., , The small-molecular Bcl-2 inhibitor venetoclax (ABT-199) () has been approved recently for the treatment of patients wi

• The current research also analyzed the association of

  2022-02-10

  

  The current research also analyzed the association of this polymorphism with HCV genotype 1-related hepatic steatosis by gender. Even though the allele and genotypes of this polymorphism an increased the risk of HCV-related hepatic steatosis, neither allele nor genotype frequency of this polymorphis

• br STAR Methods br Acknowledgments We thank Prof Y Tomari

  2022-02-10

  

  STAR★Methods Acknowledgments We thank Prof. Y. Tomari at the University of Tokyo for experimental advice and K. Hanada for technical assistance. This research was supported by Grants-in-Aid for Scientific Research on Innovative Areas “Nascent Chain Biology” (JP15H01548 and JP17H05677 to T.I. a

• br Experimental br Acknowledgements This work

  2022-02-10

  

  Experimental Acknowledgements This work was financially supported by Ministry of Knowledge and Economy (10032113) and Ministry of Education, Science and Technology (20100000297). Introduction To ensure accurate chromosome segregation, cohesion between sister chromatids must be maintained u

14913 records 481/995 page Previous Next First page 上5页 481482483484485 下5页 Last page