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Artificial permutations have also been exploited
2021-05-10

Artificial permutations have also been exploited by protein engineering to manipulate protein scaffolds, in order to improve catalytic activity, alter substrate or ligand binding affinity, reduce proteolytic susceptibility, increase stability, generate different aggregation states and improve fluore
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PDK1 inhibitor australia In agreement with the evidence on
2021-05-10

In agreement with the evidence on the Plg-binding function of tapeworm enolases, eukaryotic enolases have been shown to be multifunctional proteins, with other activities besides their role as glycolytic enzymes (Pancholi, 2001). In this respect, several flatworms have been proved to express enolase
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The total reduced glutathione content was
2021-05-10

The total reduced glutathione content was determined in both 2-Palmitoylglycerol mg to examine whether retinol was decreasing glutathione concentrations and thus decreasing the conjugation of NAPQI. Total hepatic (3.9±0.3 vs 4.9±1.0 μmol/g, retinol vs untreated, respectively) and renal (0.4±0.1 vs 0
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br Ubiquitin ligases Ubiquitin ligases
2021-05-10

Ubiquitin ligases Ubiquitin ligases are categorized into different EGTA based on their specific structural configuration and the composition of subunits—HECT (homologous to E6-AP1 (E6-associated protein 1) carboxy-terminus)-type, RING (really interesting new gene)-finger-type, U-box-type, or RING
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The goal of studying RvE in goblet cells is to
2021-05-10

The goal of studying RvE1 in goblet abscisic acid australia is to determine if it may be used to preserve ocular surface homeostasis and as a treatment of ocular inflammatory diseases. We found that RvE1 increased glycoconjugate secretion after 2 h, not at 4 h. This suggests that RvE1 has a short,
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br Localization of D receptors in striatum One characteristi
2021-05-10

Localization of D2 receptors in striatum One characteristic of D2Rs that has complicated their study is their expression in multiple neuronal populations within striatum, both pre- and postsynaptically (Beaulieu and Gainetdinov, 2011). In addition to spiny projection neurons (SPNs), which are the
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br Materials methods br Results and discussion
2021-05-10

Materials & methods Results and discussion The comparison of BFI methods (Table 1) shows that Phosphatesmo failed to detect seminal fluid in all samples. This observation is concordant with other studies that investigated water-exposed seminal fluid stains [6], [7]. The Phosphatesmo test is us
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M 1145 australia The presence of H PPases in parasitic proti
2021-05-10

The presence of H+-PPases in parasitic protists raises the question of the physiological role of these proteins. So far, they had been extensively characterized mainly in higher plants, and some prokaryotes [1], [2], [3], [4], [5], [6], [7], [16], [20]. A common feature to all these organisms is tha
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Cysteine protease activities have been suggested to be impor
2021-05-10

Cysteine protease activities have been suggested to be important for Giardia’s pathogenesis [[11], [12], [13],16,18,19,21,28,29,35]. Recently several giardial CPs were shown to be released during host cell interactions [9,10]. The three major released CPs have recently been shown to be involved in t
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br CXCR CXCR is a homeostatic chemokine receptor for lymphoc
2021-05-10

CXCR5 CXCR5 is a homeostatic chemokine receptor for lymphocytes and plays a critical role in the development of lymphoid organs as well as regulating the interaction between antigen presenting cells and lymphocytes (Cannons et al., 2012). It is one of the major chemokine receptors dictating norma
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In this study we further investigated the
2021-05-10

In this study, we further investigated the involvement of CRF1 and CRF2 receptors of the dPAG in the regulation of panic-related responses. For this, we used two animal models that associate escape behavior with panic attacks: the elevated T maze and the electrical stimulation of the dPAG (for a ful
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Experiment Blunted fear potentiated startle due to deficient
2021-05-10

Experiment 2: Blunted fear-potentiated startle due to deficient fear acquisition. SERT+/+ and SERT+/− showed significant acquisition of the cue-shock association, whereas SERT−/− did not (trial×genotype interaction: F2,50=3.3, pDiosmetin synthesis of fear-potentiated startle. Acquisition: Followi
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Co operation or synergy between PKA and Epac
2021-05-08

Co-operation or synergy between PKA and Epac has been recently reported in PCCL3 thyroid cell line in which cAMP is pro-mitogenic, in Tubacin to VSMC [19]. Our study demonstrates for the first time that PKA and Epac also synergise to inhibit cell proliferation in a cell type where cAMP in anti-mito
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br Activatable photoacoustic probes Photoacoustic
2021-05-08

Activatable photoacoustic probes Photoacoustic (PA) imaging is a recently developed technique [47]. The imaging approach uses probes that absorb a pulsed laser beam and convert light energy into acoustic signals. It combines the advantages of the high sensitivity offered by optical imaging and th
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Kinetic isotope effects KIEs inform on bond vibrational chan
2021-05-08

Kinetic isotope effects (KIEs) inform on bond vibrational changes between the ground state (GS) and TS of a chemical reaction and remain one of the most powerful experimental techniques for interrogating TS structure. KIEs on enzyme reactions measured by the internal cysteine protease of labeled su
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