• The estrogenic activity of steroids with

  2019-07-15

  

  The estrogenic activity of steroids with a C19 methyl group may provide a selective advantage in estrogen physiology that is not provided by E2. In this regard, 5α-androstanediol has been proposed to be a second physiological estrogen in fetal mouse Moxifloxacin HCl based on the timing of ERβ synth

• br Conflict of interest br Supplementary methods and materia

  2019-07-15

  

  Conflict of interest Supplementary methods and materials Acknowledgments This work was supported by an Early Career Researcher grant awarded by the Institute of Health and Biomedical Innovation to IMW and Queensland University of Technology, and grants awarded to SS by the Prostate Cancer F

• Multiple technologies exist for analyzing the

  2019-07-15

  

  Multiple technologies exist for analyzing the contents of single cells, including single-cell DNA sequencing, RNA expression analysis, and protein level and activity measurements (Hu et al., 2018; Narrandes & Xu, 2018; Ortega et al., 2017; Wang & Navin, 2015). Single-cell DNA sequencing is generally

• br Acknowledgements This research was

  2019-07-15

  

  Acknowledgements This research was supported by Slovenian Research Agency (ARRS). We thank prof. R. Marinšek Logar for helpful advice, Dr. T. Kranjc for help with data management, N. Vrhovnik and G. Lavrič for technical help with preliminary growth experiments and dr. J. Burkeljca for help with g

• To analyze EBI expression and its function

  2019-07-15

  

  To analyze EBI2 expression and its function in T cells in vivo, we created an EGFP reporter/knockout mouse strain, termed EBI2EGFP. This mouse strain in heterozygous configuration allows for a systematic analysis of the expression of EBI2 in distinct cell types in steady-state and under inflammatory

• br Results br Discussion Our UbV library was originally desi

  2019-07-15

  

  Results Discussion Our UbV library was originally designed to develop inhibitors of deubiquitinases (Ernst et al., 2013). Recently, we showed that UbVs could exhibit multiple binding modes and mechanisms to modulate HECT E3 activity (Zhang et al., 2016)—one set occupied the HECT domain E2-bind

• Celecoxib To better understand the mechanism of splicing in

  2019-07-13

  To better understand the mechanism of splicing in CLCN1, we began by constructing a minigene spanning exons 5–7 of CLCN1, resulting in the synthetic CLCN1 (5–7) minigene.

• RDH belongs to C family of the short chain dehydrogenase

  2019-07-12

  RDH10 belongs to 16C family of the short-chain dehydrogenase/reductase (SDRs) superfamily of proteins [12], [13].

• Rationale and Conventional Use of Alkylating Agents and

  2019-07-11

  Rationale and Conventional Use of Alkylating Agents and Platinum Derivatives in Clinical Practice After the attack on Bari Harbor in 1943 revealed the effects of mustard gas on bone marrow depletion and the first therapeutic outcomes in lymphoma, alkylating agents gradually became a gold standard as first-line treatment for various cancer indications.

• Mosapride Citrate The purposes of this study are to investig

  2019-07-10

  The purposes of this study are to investigate the molecular function of DDR2, especially in cellular proliferation in prechondrocytes, and to examine the relationship between the proliferation and differentiation of prechondrocytes through both in vitro and in vivo analysis.

• Diagnosis of NCC can be

  2019-07-09

  Diagnosis of NCC can be accomplished via imaging techniques and serological confirmatory testing.

• Materials and methods Results Discussion For

  2019-07-08

  Materials and methods Results Discussion For many years, oral PDE5-Is have been prescribed as an on-demand regimen for treating ED. Several studies have reported on the efficacy and safety of such a regimen, with an overall efficacy rate of 60–70% [21].

• A widely accepted mechanism to differentiate

  2019-07-05

  A widely accepted mechanism to differentiate hESCs into cardiomyocytes is through perturbation of the canonical Wnt/β-catenin pathway.

• Furthermore down regulation of Cpt a ApoE Fasn

  2019-07-04

  Furthermore, down-regulation of Cpt1a, ApoE, Fasn, Pxr, and Srebp-1 genes indicates a down-regulation of lipid metabolism associated genes while Fatp1 is up-regulated and indicates an increase in fatty Rac GTPase fragment transport genes involved in accumulation [84,85].

• Related with the studies by Zizza et

  2019-07-03

  Related with the studies by Zizza et al. described above [66], work by Ward et al. [68] suggested that the C2 domain of cPLA2α, which binds to zwitterionic membranes with high affinity in a Ca2+-dependent manner, has a high membrane remodeling activity, producing dramatic changes in membrane curvature consistent with the role of cPLA2α in the formation of the phagosome.

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